President, COO, Alnylam
And as of late, some of this work looks like it's begun to pay off. In 2004, Alnylam published a study in Nature showing that RNAi worked in rodents, and another in 2006 that documented RNAi's effect in primates. Earlier this year, RNAi was shown to work in humans, with proof of concept. Meanwhile, the company has secured several premium partnerships, including a whopping $1 billion discovery deal with Roche.
The culture at Alnylam reflects this excitement. "It's not uncommon to see scientists high-fiving in the hallways or working collaboratively," says Greene. And why shouldn't they? "Every morning, we can get up and say we're going to impact disease—and that's exactly what we should be doing. If you drift to far from that, you make mistakes."