Since receiving his PhD in economics from Princeton University in 1967, Grabowski, along with numerous collaborators, has made wide-ranging contributions in the economics of R&D and innovation and regulatory policy. Although best known for his work in the biopharmaceutical sector, he has also published in other areas, such as cost-effectiveness analyses, auto insurance and safety regulation, and the life cycle and managerial models of the firm.
Over the years he has made numerous other professional contributions—testifying before Congress, presenting at innumerable public policy forums, serving on the American Enterprise Institute Health Advisory Board, providing leadership on journal editorial boards, and rendering consulting services (often pro bono) to the National Academy of Sciences, the Institutes of Medicine, the Federal Trade Commission, and the General Accounting Office, to name just a few.Grabowski's research on pharmaceuticals evolved gradually after he arrived at Duke University in 1972. First was the award of an NSF grant to study the effects of the 1962 Amendments to the Food and Drug Act on drug innovation incentives. This was followed by an NSF grant to study market competition in pharmaceuticals more broadly, including the role of patents, generic competition, and government regulatory and reimbursement policies. In the early 1980s Professors Grabowski and John Vernon also decided to establish the program in Pharmaceuticals and Health Economics at Duke at a time when few other economists were studying the industry on a consistent basis.
Several important articles by Grabowski and Vernon on the impact of the 1984 Hatch-Waxman Act appeared in the mid '80s, followed by a simulation model of the R&D process in pharmaceuticals and an analysis of Medicaid patients' access to new drug approvals. But it was in the 1990s that he coauthored five articles that are legitimately characterized as "grand slams"—articles that continued his collaboration with Vernon, and initiated new collaborations with Joseph A. DiMasi, Ronald W. Hansen, and Louis C. Lasagna. Three of these now-classic articles quantified the risks, returns, and costs of innovation in the pharmaceutical industry, while two quantified the impact of the Hatch-Waxman legislation on brand loyalty and generic entry and pricing.