Imagine a footrace. A hundred runners assemble at the starting line, but when the starter's pistol goes off, ten of them change their minds and don't run at all. At the first turn, another dozen drop out: They're too far behind, and they feel like they can never catch up. Halfway into the race, still more quit: They're tired, they're sore, and they don't think they can make it. With the finish line in sight, still more grind to a halt: They haven't paced themselves, and they can't go on. By the time the runners reach the finish line, only a handful are left.
In real life, races don't usually work that way, partly because of good coaching. Runners are motivated by their coaches to train and prepare for the race. They learn how to handle the obstacles of the course and develop a frame of mind so that they can endure. They prepare not just for the starter's gate, but for the entire course.
Running the Race A 2003 survey conducted by Prevention magazine tested consumer awareness of DTC advertising for 13 medicines prescribed for chronic conditions such as arthritis, high blood pressure, and depression. The data showed that eight of every 100 people who read a DTC ad received a prescription.
But how many persist in taking the medication? An earlier Prevention survey paints a striking picture. In that 1999 survey, seven patients out of 100 received a prescription. Six filled it. Four made it to the first refill. But by the fourth or fifth refill, only one was still taking the medication.
Think of it another way: If all six patients who filled their prescriptions made it to the fourth refill, the manufacturer would have made 30 sales-six patients times five visits to the pharmacy. In fact, the manufacturer makes only 16 sales, a loss of almost 50 percent.
But that scenario applies only to the fourth or fifth refill. Medications for chronic conditions could be prescribed for months or years. If patients can be persuaded that it is in their best interest to refill the prescription and stay on the therapy as prescribed, the product's return on investment (ROI) would skyrocket. Patients who remain in therapy and manage their medications correctly also have a better clinical response and physicians are more inclined to prescribe the medication to other patients.
Why do patients drop out of therapy prematurely? The 2003 Prevention survey lists several reasons: failure to remember; started feeling better; forgot to get refill; cut recommended dose because medicine is too strong; took less so prescription would last longer; and side effects. Perhaps some of those reasons would be eliminated if pharmaceutical patient communications focused more on health literacy as part of their patient compliance strategies.
Reducing the Dropout Rate Pharma companies have good reason to be concerned that so many patients with chronic conditions are dropping out of therapy prematurely. Not only does that drastically decrease the campaign's potential ROI, but a commonly used advertising statistic maintains that it costs six times more to gain a new patient than to retain a current one.
Yet, there is no quick fix. To persuade patients to remain in therapy, pharma marketers must develop a compliance strategy that meets the varying needs of consumers, patients, and health professionals through all stages of treatment. It must take into account the specific product, disease, and patient population. A patient compliance strategy must be part of the DTC program and subsequent patient information materials.
Three-Step Program When DTC is conceptualized as the first stage of a larger patient compliance program, the stage is set for educational messages that can help patients answer three key questions:
The Prevention study found that providing risk information in a DTC message may actually increase consumer confidence in the advertised product. And if patients trust what the DTC promotion says, they are more likely to fill the initial prescription. Compliance also increases when patients feel they are part of the decision-making process. Because DTC programs target people as they are about to make a therapeutic decision and encourage them to become more informed, they have the potential to improve initial prescription fill rates.
To make an accurate risk/benefit assessment, consumers must be able to understand the information presented. There is a wide disparity in the quality of materials distributed to patients, according to an eight-state study published in the May/June 2003 issue of the Journal of the American Pharmacists Association. And many materials fail to inform patients. A survey conducted by the Department of Psychiatry at Louisiana State University Medical Center in 2000 showed that almost half of all patients were unable to understand pharmacy printouts.
Many companies still use the highly technical "brief summary" with consumer materials, but the FDA-approved patient package insert (PPI) is easier to understand and should become the foundation of all patient information programs, including DTC ads. (See "Words to the Wise.")
How do I take this medication? At least 50 percent of the people who get prescriptions for chronic medications do not take them correctly. That is usually because they do not receive enough information, they fail to understand the information the pharmacy provides, or they choose to ignore it. If the patient makes an error, the drug will not be as effective as it should be, often leading the doctor to switch the patient to another medication.
Prevention's 1999 survey found that three in ten patients already taking a product said they were more likely to take the prescribed medicine after seeing it advertised. The magazine's 2003 survey suggests that DTC advertising might make consumers feel better about the safety and effectiveness of the medicines they are taking, but the survey did not address the impact of this effect on compliance.
Why should I refill my prescription? Patients decide if they're going to finish-or lengthen-their course of therapy, based on their symptoms, side effects, and feedback from health professionals.
DTC programs tied to an overall patient compliance strategy can help improve refill compliance and increase patient retention. In the 1999 Prevention survey, one third of patients said DTC ads reminded them to refill their prescriptions. And consumers who see a DTC ad for a product they currently take are significantly more likely than others to say the ad made them more confident about their medication.