Vice President of Business Development and New Product Planning, Alkermes
When Pfizer discontinued Exubera, its disastrously unsuccessful inhaled insulin, in 2007, the soul searching wasn't limited
to Manhattan's East 42nd Street. One of the companies that found itself reeling was Alkermes, a biotech with deep experience
in drug delivery, which had been partnering with Lilly on a prospective inhaled insulin product—one that Lilly cancelled not
long after Exubera bit the dust."That caused us to really take stock of what we were doing and how we were moving forward,"
recalls Blair Jackson. At the time the Lilly project was pulled, Alkermes had only one proprietary program in development,
Vivitrol (naltrexone) for alchohol dependency; the rest of the company's resources were focused on developing drugs for partners.
Suddenly that ratio looked wrong. "Over the course of the next year," says Jackson, "we moved from being a single- to a multiple-product
developing company. We ended up doing more than 25 clinical and nonclincal studies. We had five or six regulatory filings.
It was a fundamental shift in the organization." And leading the way was Jackson's program leadership team. The lessons of
turning the battleship? "One of the most important things is flexibility," says Jackson. "When you look at severeal development
programs at once, you find that the plan going in at the beginning of the year is completely different from the plan coming
out at the back end. But what does remain the same is the budget."