William Looney
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To climatologists, April is a transitional month, when the frozen fields of winter yield to showers that prime the soil for
renewed growth. This month's issue of Pharm Exec tracks this same timeless pattern, but in reverse. Two feature stories illustrate
how the next generation of industry leaders is managing the change from an era of plenty to today's harvest of scarcity, where
the soil for science is fallow and the seeds of drug discovery take much longer to root.
Our cover profile of 2010 HBA Woman of the Year honoree Deirdre Connelly of GSK, and a Q&A with Pfizer's Specialty Care business
lead Geno Germano, both suggest that success in this harsh commercial climate depends on one overriding factor: the ability
to read, interpret, and anticipate business conditions through the eye of the customer. This skill is followed closely by
leadership acumen, where top management must set the example for clarity, consistency, and integrity in meeting business objectives.
Connelly's background makes her one of the few industry leaders with direct experience in the human resources function. HR
has been a neglected aspect of management in flush times, but one which should garner increased visibility as companies look
to wrest higher productivity from a smaller work force. One testimonial cites her approachability to junior staff, based on
a simple reference point: "I don't know—teach me." Few words matter more now that responsibility for executing strategy is
being pushed to a new generation of "empowered" managers often barely out of their thirties.
An adjunct to Connelly's curiosity is Geno Germano's commitment to the "light touch" in meeting tougher standards for access
to high-priced specialty medicines. Strong analytics are critical, but represent a defensive mindset. Obtaining a premium
price based solely on quantitative evidence of "value differentiation" is going to be much harder when it is sown in the parched
terrain of patent expiries and genericization. It's best to venture a step beyond economics to mobilize the people power that
drives partnerships. As Germano notes, this requires costly, time-intensive investments in human capital, where customers
are engaged at an early stage in the product development cycle and are bonded to a service orientation that involves the entire
resources of the organization for the long-term. It's a strategy drawn to complement the human profile—in other words, "customer
facing."
The competitive advantage from embracing insight and intuition to get closer to customers is hard to quantify in the standard
business plan. But a third feature this month, on the brave "neuro" world of cognitive enhancement therapies, suggests there
may be a solution at hand. You guessed it: a new drug. Senior Editor Walter Armstrong tracks the scientific hurdles, ethical
dilemmas, and regulatory fault lines confronting the evolving field of cosmetic neurology. Big Pharma is exploring potential
applications against age-related conditions, but full use of the brain's softer right hemisphere is going to be needed to
anticipate the reputational mine fields of spending scarce research dollars merely to make otherwise healthy people "smarter."
The April issue ends with a pessimistic brief examining the work of Lilly executive Bernard Munos, on the scope of the industry's
productivity challenges in conducting R&D. Munos' calculations lead him to conclude that industry must embrace a new research
model, as current efforts to address the gap in NCEs —including mergers, out-licensing, and cost cuts—are insufficient when
measured against the impact of a risk-averse regulatory and payer climate. He notes that the trend toward industry consolidation
is dangerous. Despite rhetoric to the contrary, no large organization has the tolerance for the "disruptive" innovation that
tends to produce the most medically significant breakthroughs.
William Looney
Editor-in-chief
wlooney@advanstar.com
PharmExec Blog
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