Rheumatoid Arthritis: JAKing Down Inflammation - Pharmaceutical Executive

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Rheumatoid Arthritis: JAKing Down Inflammation


Pharmaceutical Executive



In the race to market the first oral drug to compete with high-priced injectables for rheumatoid arthritis (RA), Pfizer's tasocitinib has the home-stretch lead over Rigel, Vertex, and Incyte. All four contenders are Janus-associated kinase (JAK) inhibitors, a new class of molecules with anti-inflammatory activity that puts the brakes on RA's joint destruction. In a 600-patient Phase III trial, Pfizer's twice-daily anti-JAK pill reached two of three of its goals, reducing symptoms and increasing functionality, but failing to best placebo in number of remissions. Three out of four patients saw a decrease in pain and inflammation. However, the drug raised the levels of both good and bad cholesterol, a regulatory red flag, especially for drugs used long term by elderly patients. As a first-to-market RA pill, tasocitinib could garner $2 billion annually in sales, says Sanford C. Bernstein & Co's Tim Anderson.

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