Advantages of MLC

Product Co-Positioning and Segmentation Procter & Gamble identified nine different laundry detergent segments, each with unique needs, and has distinctly positioned each brand (Bold, Cheer, Dash, Dreft, Era, Gain, Ivory Snow, Oxydol, and Tide) to meet the needs of these segments. For example, with a tag-line of "gentle as a mother's touch," Dreft detergent is "specially formulated for baby clothing and other items." Similarly, Abbott will be positioning its five dyslipidemia agents for specific patient segments with different combinations of LDL, HDL, and triglyceride abnormalities.

Combinations of Products Abbott has leveraged its dyslipidemia franchise by combining products into single pills, including the developmental combination of its fibrate TriLiplix with AstraZeneca's statin Crestor. Roche tries to maximize its oncology portfolio by demonstrating the benefits of a combined regimen in clinical trials. For example, in the recent ATLAS trial, Roche's Avastin combined with its cancer pill Tarceva extended the period without disease progression in patients with advanced lung cancer.

Shelf Space Abbott will likely use its five cholesterol products to take up space in physicians' supply cabinets. GSK tries to capture the limited available space for vaccines in the pediatrician's office refrigerator, thereby minimizing space for competitors.

Pricing/Contracting GSK encourages vaccine payers to purchase from its extensive portfolio of vaccine products by offering volume incentives. Roche's extensive oncology portfolio provides it with substantial negotiating leverage.

Sales/Stakeholder Relationships Because of its long term focus on the diabetes marketplace, Novo has a tremendous relationships with diabetes prescribers, thought leaders, professional societies, and other key stakeholders.

Cost/Operating Efficiencies Novo's focus on a range of diabetes products, particularly insulin formulations, has created economies of scale, resulting in a lower cost structure and higher profitability. For example, the company has made its pen-filling station more efficient by using similar parts for components of all pens. Roche and GSK gain manufacturing efficiencies by using their plants to produce multiple biologic and vaccine products, respectively. Such efficiencies drive down product costs and provide these companies with a lower competitive-cost basis and higher margins.

Business Development/Licensing The competition to license or acquire innovative pharmaceutical compounds is increasingly intense. Companies that focus on specific franchises or portfolios have a competitive advantage in attracting partners due to extensive market experience, long-standing customer relationships, and established capabilities.

Winning with MLC

There are several ways for pharmaceutical companies to successfully implement multi-level competition. These include:

Incorporate MLC into strategy and marketing plans Every corporate, portfolio, franchise, and brand plan should include sections on competing at all four levels. These sections should identify the levels where the company and competitors have relative advantages, and describe how to leverage or offset those advantages. Ultimately, strategists and marketers need to operate on the level or levels that provide the greatest chance for success.

Build, buy, extend, and/or partner for enhanced levels There are different ways to enhance the competitive value of a brand, franchise, portfolio, or company. For example, Abbott initiated its cholesterol franchise with a single fibrate product, purchased Kos Pharmaceuticals to add niacin agents, created a second generation fibrate, and then partnered with AstraZeneca to develop a combination branded statin-fibrate product. To augment its diabetes franchise, Novo Nordisk is developing novel insulin formulations and combinations as well as new GLP-1 class agents, and has formed external research alliances to develop insulin-producing stem cells. To better compete with Novo, Eli Lilly recently announced an alliance with device manufacturer Medtronic to combine their insulin products, insulin pump therapy, and continuous glucose-monitoring capabilities. Likewise, in order to compete with HIV industry leader Gilead Sciences, GSK and Pfizer recently formed a joint venture company to combine their HIV portfolios. GSK's CEO Andrew Witty said, "You blend our portfolio with [Pfizer's] and you cover a range of different targets in a range of different ways, which is a valuable benefit."

Test the franchise management strategy Increasingly, market-leading pharmaceutical companies are conducting not only brand but also franchise, portfolio, and corporate war games. The most progressive of these companies conduct "Competitive Simulations," an improved version of war games specifically designed to role-play, pressure-test, and validate a company's—and its competitors'—strategies and tactics, including multi-level competition, in a simulated market environment.

Companies using MLC approaches generally demonstrate deeper customer knowledge, enhanced stakeholder relationships, improved efficiencies, better ROI, significant competitive advantages, and, ultimately, better sales in their product categories. Importantly, while many pharmaceutical companies have multi-brand franchises or portfolios and designated business leaders, relatively few companies fully leverage powerful multi-level competition strategies, techniques, and tactics to win against companies relying on single brands.

Stan Bernard, MD, MBA is President of Bernard Associates, LLC, a pharmaceutical industry management consulting firm. He can be reached at SBernardMD@BernardAssociatesLLC.com