According to the American College of Physicians, recent years have seen a significant drop off in the number of doctors entering primary care practices. US medical-school surveys found that in 1998 more than half of all third-year residents intended to pursue general medicine. By 2005, the number had dropped to one in five. As clinical demand increases, nurse practitioners (NPs) and physician assistants (PAs) are practicing with greater autonomy and prescribing more medication than ever before—approximately 750 million prescriptions per year. NPs and PAs represent a major component of our present and future healthcare delivery system, yet historically the pharmaceutical industry has considered them secondary targets.