Equipment and Processing Report, Feb 15, 2012 - Pharmaceutical Technology

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Equipment and Processing Report, Feb 15, 2012
Production Lines
Mid-Size Extruders Enable Scale-Up of Hot-Melt Extrusion
By Jennifer Markarian
With the increasing use of hot-melt extrusion, extruder manufacturers have developed mid-size twin-screw extruders that facilitate process development and scale-up to commercial processes.
In the Mixer
Comparing Lyophilization in Vials and Dual-Chamber Systems
By Joerg Zimmermann
The author discusses the relative advantages and disadvantages of lyophilization in vials and dual-chamber systems.
Troubleshooting
Determining Whether Dry-Dispersion Can Be Used in a Laser-Diffraction System
We need to measure the particle size of a moisture-sensitive powder. We would like to use dry analysis on our laser-diffraction system, but the particles are fragile and we're struggling to get robust results. Is wet measurement with a nonaqueous solvent the only option?
Editor's Picks
February 2012 Editor's Picks: Products from ACS Valves and G-Con Manufacturing
PharmTech's monthly newsletter, Equipment and Processing Report, reviews the Editor's Picks for the February 2012 edition from ACS Valves and G-Con.

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Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
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