Pharmaceutical Executive Daily: Retatrutide's Positive Phase III Trial Results

Welcome to Pharmaceutical Executive Daily, your quick briefing on the top news shaping the pharmaceutical and life sciences industry.

In today’s Pharmaceutical Executive Daily, Eli Lilly reports positive topline Phase III results for retatrutide, the FDA expands Amgen’s Uplizna label into generalized myasthenia gravis subtypes, and a new analysis explores whether pharmaceutical manufacturing is truly moving back onshore.

Eli Lilly has announced positive topline results from a Phase III trial of retatrutide, its investigational triple-hormone receptor agonist for obesity and metabolic disease. The study met its primary endpoints, reinforcing retatrutide’s potential as a next-generation therapy in an increasingly competitive cardiometabolic landscape.

In regulatory news, the FDA has approved an expanded indication for Amgen’s Uplizna to treat adults with generalized myasthenia gravis who are anti–acetylcholine receptor or anti-MuSK antibody positive. The decision broadens treatment options for patients across multiple disease subtypes and strengthens Uplizna’s position in rare neuromuscular disorders.

Meanwhile, a new industry analysis examines whether pharmaceutical manufacturing is truly returning to domestic markets, citing persistent challenges including cost pressures, workforce shortages, and complex supply chains. While policy incentives have accelerated select investments, the report suggests widespread reshoring remains uneven and highly product dependent.

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