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With the globalization of the pharmaceutical industry, multiregional clinical trials (MRCTs) have steadily increased over the past decade. In March 2016, the Centre of Regulatory Excellence (CoRE), Duke-NUS Medical School Singapore – recently designated as an APEC Center of Excellence (CoE) for regulatory training in MRCTs – organized and hosted the second APEC CoE MRCT Workshop in Singapore, following the successful pilot Workshop in Singapore in 2014.